6 Dec 2018

NEW DNA TESTS FOR DANES

We already test for CNM aka IMGD and this is another test for Great Danes. 


Leukoencephalomyelopathy (LEMP) in Rottweilers and Great Danes
Leukoencephalomyelopathy (LEMP) is a neurodegenerative disorder of the central nervous system. LEMP is characterized by a generalized, progressive loss of balance with increasing immobility. Signs of LEMP often appear prior to 1 year of age, typically presenting as gait abnormalities including dragging of paws and knuckling.  The disease is progressive, moving from front to back limbs but is not associated with pain.

LEMP in Rottweiler dogs results from insertion of one base in the NAPEPLD gene (c.345_346insC), reported here as LEMP. The disease is inherited in an autosomal recessive fashion, which means that males and females are equally affected and that two copies of the defective gene are needed to cause LEMP. Dogs with one normal and one affected gene (carriers) are normal and show no signs of the disease. This variant is also present in Great Danes, therefore, testing for this breed is advisable.

The Veterinary Genetics Laboratory offers a genetic test for the mutation associated with LEMP in Rottweiler and Great Dane breeds. Test results assist veterinarians with a diagnosis of LEMP and help breeders identify carriers among breeding stock to avoid producing affected dogs. Matings between carriers are expected to produce 25% of affected puppies.
Testing is appropriate for Rottweilers, Great Danes

FROM UC DAVIS WEBSITE

You can get this test also from labokin but I personally use the above for all my own dogs you can use whichever is easier for yourselves

For me, this test should be done more so if you have an imported dog including those from the ancestry in your Great Danes.

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